| 发明名称 |
FKBP-type immunophilin inhibitors |
| 摘要 |
<p>A compound of formula (I), substituents defined within; and a process for its preparation, whereby a compound of formula (II) is reacted with a compound of formula (III). Compounds of formula (I) have an affinity for and act as inhibitors of FKBP-type immunophilins (particularly FKBP-12 and FKBP-52), without inhibiting the protein phosphatase calcineurin thus lacking any significant immunosuppressive activity.</p> |
| 申请公布号 |
NZ508839(A) |
申请公布日期 |
2003.01.31 |
| 申请号 |
NZ19990508839 |
申请日期 |
1999.07.01 |
| 申请人 |
PFIZER, INC |
发明人 |
MAGUIRE, ROBERT JOHN;BLAKE, JAMES FRANCIS;WYTHES, MARTIN JAMES;PALMER, MICHAEL JOHN;KEMP, MARK IAN;MACKENNY, MALCOLM CHRISTIAN |
| 分类号 |
C07D401/14;A61K31/4184;A61K31/423;A61K31/428;A61K31/445;A61K31/5377;A61P21/00;A61P21/04;A61P25/14;A61P25/16;A61P25/28;A61P43/00;C07D211/60;C07D401/04;C07D413/04;C07D413/14;C07D471/14;(IPC1-7):C07D413/04;A61K31/41 |
主分类号 |
C07D401/14 |
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