| 发明名称 |
POLYCYCLOALKYLPURINES AS ADENOSINE RECEPTOR ANTAGONISTS |
| 摘要 |
The invention is based on the discovery that compounds of formula are unexpectedly highly potent and selective inhibitors of the adenosine A1 receptor. Adenosine A1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory diseases. and many diseases for which diuretic treatment is suitable. 43 claims, 8 figures
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| 申请公布号 |
BG106762(A) |
申请公布日期 |
2003.01.31 |
| 申请号 |
BG20020106762 |
申请日期 |
2002.05.31 |
| 申请人 |
BIOGEN INC. |
发明人 |
KIESMAN, WILLIAM F.;DOWLING, JAMES E.;ENSINGER, CAROL L.;KUMARAVEL, GNANASAMBANDAM;PETTER, RUSSELL C.;CHANG, HE X.;LIN, KO C. |
| 分类号 |
A61K31/52;A61K31/522;A61K31/661;A61K31/662;A61P1/16;A61P3/00;A61P3/10;A61P7/10;A61P9/00;A61P9/02;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P11/16;A61P13/12;A61P17/02;A61P25/16;A61P25/24;A61P25/28;C07D453/02;C07D473/06;C07D473/22;C07D493/08;C07D519/00;C07F9/6561;(IPC1-7):C07D493/08 |
主分类号 |
A61K31/52 |
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