The present invention provides medicament-containing cyanoacrylate adhesive formulations for sealing wounds. The adhesive comprises a cyanoacrylate, a substance, and a defect forming agent, wherein the defect forming agent is capable of being removed from a cured cyanoacrylate matrix by solvation in an aqueous solution whereby a plurality of defects in the matrix are formed permitting release of the substance from the matrix at a controlled rate.
申请公布号
WO03008003(A1)
申请公布日期
2003.01.30
申请号
WO2002US23222
申请日期
2002.07.19
申请人
LOMA LINDA UNIVERSITY MEDICAL CENTER;ZHU, YONG-HUA;KIRSCH, WOLFF, M.;DICKSON, CINDY;GU, MIN, DI;YANG, CHANG, ZHENG;SHEN, QUN-DONG