发明名称 |
METHOD FOR THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHOLOGICAL DISORDERS |
摘要 |
The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administration of a suitable DP IV inhibitor leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) in the brain of mammals. Such treatment will result in a reduction or delay in the decrease of the concentration of functionally active neuronal NPY (1-36). As a consequence of the resulting enhanced stability of the endogenous NPY (1-36), NPY activity is prolonged thereby resulting among other things in functionally active NPY YI receptor activity thereby facilitating antidepressive, anxiolytic, analgesic, antihypertension and other neurological effects. |
申请公布号 |
WO0234243(A3) |
申请公布日期 |
2003.01.30 |
申请号 |
WO2001EP12479 |
申请日期 |
2001.10.29 |
申请人 |
PROBIODRUG AG;VON HOERSTEN, STEPHAN;KASK, ANTS;DEMUTH, HANS-ULRICH;HOFFMANN, MATTHIAS;KRUBER, SUSANNE;NGUYEN, HUU, PHUC |
发明人 |
VON HOERSTEN, STEPHAN;KASK, ANTS;DEMUTH, HANS-ULRICH;HOFFMANN, MATTHIAS;KRUBER, SUSANNE;NGUYEN, HUU, PHUC |
分类号 |
A61K45/00;A61K31/00;A61K31/17;A61K31/40;A61K31/426;A61K38/00;A61K38/17;A61P1/14;A61P9/12;A61P21/02;A61P25/00;A61P25/04;A61P25/08;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/36;A61P29/02;A61P43/00;C07D277/04 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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