| 摘要 |
<p>It is intended to provide a method of efficiently screening a substance promoting the active transport of an ABC protein or a substance inhibiting the same, characterized by comprising: (a) transferring an ABC protein gene into highly drug-sensitive yeast cells to thereby construct transformed yeast cells having the ABC protein expressed on the cell membrane; (b) culturing the transformed yeast cells in the presence of a substance, which is transported outside the cells by the ABC protein occurring in the cell membrane and has a cytotoxicity on the yeast cells, and a test substance; (c) and comparing the growth level with the case where the cells are cultured in the absence of the above-described test substance.</p> |
