发明名称 |
Fluidic temperature gradient focusing |
摘要 |
A method and device are provided for concentrating and separating ionic species in solution within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is achieved by balancing the electrophoretic velocity of an analyte against the bulk flow of solution in the presence of a temperature gradient. Using an appropriate buffer, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity so that the electrophoretic and bulk velocities sum to zero at a unique point and the analyte will be focused at that point. The method and device may be adapted for use with a variety of analytes including fluorescent dyes, amino acids, proteins, DNA and to concentrate a dilute analyte.
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申请公布号 |
US2003019752(A1) |
申请公布日期 |
2003.01.30 |
申请号 |
US20020197331 |
申请日期 |
2002.07.18 |
申请人 |
ROSS DAVID;LOCASCIO LAURIE E. |
发明人 |
ROSS DAVID;LOCASCIO LAURIE E. |
分类号 |
G01N27/447;(IPC1-7):G01N27/26 |
主分类号 |
G01N27/447 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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