| 摘要 |
<p>The present invention identifies different activities mediated by eosinophil PGD2 receptors and features methods measuring the ability of a compound to modulate such activities. Activities mediated by eosinophil PGD2 receptors include those associated with CRHT2 and those associated with the DP receptor. Activities identified herein as associated with eosinophil CRHT2 include a change in cell morphology, degranulation, and a specific chemokinetic effect. Activities identified herein as associated with the eosinophil DP receptor include resistance to apoptosis.</p> |
