NUCLEIC ACIDS ENCODING CD40/CD40L CHIMERIC POLYPEPTIDES, METHODS FOR THEIR PRODUCTION AND USES THEREOF

摘要

A nucleic acid encoding a CD40/CD40L chimeric polypeptide comprising nucleic acid fragments encoding i) the signaling domain of CD40 and downstream thereof, ii) a transmembrane domain of a type II receptor and downstream thereof iii) the binding and trimerization domain of CD40L, is useful as a gene therapy agent for the local treatment of solid tumors.