发明名称 |
Scar reduction |
摘要 |
A method of reducing scar formation at a wound site includes contacting the wound site with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge and thereby reducing scar formation as the wound site heals. Such polysaccharide include bioabsorbable cross-linked dextrans or alginates. The positive charge may be provided by diethylaminoethyl (DEAE) moieties. The cross-linked polysaccharide can be applied to the wound site as a powder or bead. The cross-linked polysaccharide may also be contained in a composition including a pharmaceutically acceptable vehicle. Biocompatable surgical devices are provided with an effective scar reducing amount of a cross-linked polysaccharide having a positive charge which reduce scar formation at healing wound sites. A method of reducing TGF-beta activity is also provided.
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申请公布号 |
US2003023209(A1) |
申请公布日期 |
2003.01.30 |
申请号 |
US20020058182 |
申请日期 |
2002.01.25 |
申请人 |
UNITED STATES SURGICAL CORPORATION |
发明人 |
GRUSKIN ELLIOTT A.;CHISTOFOROU CHRISTOFER T. |
分类号 |
A61K31/715;A61K31/738;A61L17/14;A61L27/34;(IPC1-7):A61F2/02;A61L17/00;A61B17/04;A61M35/00 |
主分类号 |
A61K31/715 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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