The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
申请公布号
WO03008550(A2)
申请公布日期
2003.01.30
申请号
WO2002US22739
申请日期
2002.07.17
申请人
ISIS PHARMACEUTICALS, INC.;MOORE, MAX, N.;KROTZ, ACHIM;ANDRADE, MARK;SCOZZARI, ANTHONY, N.
发明人
MOORE, MAX, N.;KROTZ, ACHIM;ANDRADE, MARK;SCOZZARI, ANTHONY, N.