REMEDIES FOR BRAIN ISCHEMIC DISEASES

摘要

Remedies and/or preventives for brain ischemic diseases comprising two active ingredients, namely, an astrocytic function−improving agent, preferably a compound represented by the following general formula (I), and a thrombolytic agent, preferably a tissue plasminogen activator: (I) wherein R6 represents hydroxy, etc.; and (1) n is 1, R11 represents hydrogen, and R5 represents (alkyl having a fluorine atom as a substituent of a carbon atom)−CH2−; or (2) n is 0 or 1, R11 represents hydrogen, etc., and R5 represents alkyl, etc. These drugs show synergistic therapeutic effects compared with the case where an astrocytic function improving agent and a thrombolytic agent are separately administered.