发明名称 |
Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels |
摘要 |
Markedly enhanced activity of pacemaker (hyperpolarization-activated, cation-nonselective, HCN) ion channels governs spontaneous firing in sensory cells of allodynic rats. An HCN ion channel specific blocker, ZD7288, dose-dependently and completely suppresses allodynia. Nerve injury increases the population of large DRG neurons expressing a high density of Ih and modulates HCN mRNA expression. New methods of treating pain by targeting HCN pacemaker channels are developed. In addition, new methods for identifying compositions useful for treating pain are disclosed.
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申请公布号 |
US2003022813(A1) |
申请公布日期 |
2003.01.30 |
申请号 |
US20020158711 |
申请日期 |
2002.05.30 |
申请人 |
CHAPLAN SANDRA;DUBIN ADRIENNE;GUO HONG-QING;LEE DOO HYUN;LIU CHANGLU;LUO LIN;BROWN SEAN |
发明人 |
CHAPLAN SANDRA;DUBIN ADRIENNE;GUO HONG-QING;LEE DOO HYUN;LIU CHANGLU;LUO LIN;BROWN SEAN |
分类号 |
A61K45/00;A61K31/00;A61K31/135;A61K31/167;A61K31/195;A61K31/197;A61K31/4166;A61K31/4168;A61K31/485;A61K31/4965;A61K31/505;A61K31/53;A61K31/55;A61K31/7105;A61K39/395;A61K45/06;A61K48/00;A61K49/00;A61P3/10;A61P9/10;A61P19/02;A61P25/00;A61P25/02;A61P25/04;A61P25/06;A61P27/02;A61P29/00;A61P31/18;A61P35/00;A61P37/02;A61P43/00;C07K16/18;C12N15/09;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):A61K31/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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