| 摘要 |
The invention provides an isolated nucleic acid molecule encoding a novel human sodium channel protein beta subunit. This nucleic acid molecule encodes a transmembrane protein that bears substantially sequence similarity to mammalian sodium channel protein beta subunits. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.
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