发明名称 |
USES FOR MEDICAL DEVICES HAVING A LUBRICIOUS, NITRIC OXIDE-RELEASING COATING FOR THE THERAPY OF VASCULAR DISORDERS |
摘要 |
Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medicaldevice coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidine, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid. |
申请公布号 |
WO0243786(A3) |
申请公布日期 |
2003.01.30 |
申请号 |
WO2001US43719 |
申请日期 |
2001.11.20 |
申请人 |
MEDTRONIC AVE INC.;TEDESCHI, EUGENE;SHAH, CHIRAG, B. |
发明人 |
TEDESCHI, EUGENE;SHAH, CHIRAG, B. |
分类号 |
A61M31/00;A61K33/00;A61L27/00;A61L27/34;A61L27/54;A61L29/00;A61L29/08;A61L29/16;A61L31/00;A61L31/10;A61L31/16;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P11/16;A61P13/08;A61P31/04 |
主分类号 |
A61M31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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