发明名称 |
COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF |
摘要 |
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula (I), wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease; a pharmaceutical composition, a commercial package or product comprising such a combination; the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal. |
申请公布号 |
WO03007924(A2) |
申请公布日期 |
2003.01.30 |
申请号 |
WO2002EP08020 |
申请日期 |
2002.07.18 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.;CHEN, TIANLING;GREELEY, DIANE;ROTHERMEL, JOHN, DAVID;WARTMANN, MARKUS;WOOD, JEANETTE, MARJORIE |
发明人 |
CHEN, TIANLING;GREELEY, DIANE;ROTHERMEL, JOHN, DAVID;WARTMANN, MARKUS;WOOD, JEANETTE, MARJORIE |
分类号 |
A61K31/00;A61K31/282;A61K31/427;A61K31/429;A61K31/502;A61K31/555;A61K31/663;A61K31/675;A61K33/24;A61K45/00;A61K45/06;A61P35/00;A61P43/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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