| 发明名称 |
SULFONYL ARYL HYDROXAMATES AND THEIR USE AS MATRIX METALLOPROTEASE INHIBITORS |
| 摘要 |
The invention is directed to sulfonyl aromatic hydroxamic acid compounds and salts thereof that, inter alia, inhibit matrix metalloprotease (MMP) activit y and/or aggrecanase activity. In some particularly preferred embodiments, the compound corresponds in structure to one of the following formulas: (I) (II) wherein W2, the R groups, and -A-R-E-Y are described in more detail in Applicants'specification. This invention also is directed to a process that comprises administering such a compound or pharmaceutically acceptable salt thereof to a host animal having a condition associated with MMP activity.</S DOAB>
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| 申请公布号 |
CA2453613(A1) |
申请公布日期 |
2003.01.30 |
| 申请号 |
CA20022453613 |
申请日期 |
2002.07.19 |
| 申请人 |
PHARMACIA CORPORATION |
发明人 |
BECKER, DANIEL P.;BARTA, THOMAS E.;DE CRESCENZO, GARY A.;RAO, SHASHIDHAR N.;MISCHKE, BRENT V.;BEDELL, LOUIS J.;VILLAMIL, CLARA I.;MCDONALD, JOSEPH J.;GETMAN, DANIEL P.;FRESKOS, JOHN N. |
| 分类号 |
C07D295/22;A61K31/445;A61K31/451;A61K31/4525;A61K31/453;A61K31/4535;A61K31/454;A61K31/4545;A61K31/495;A61P1/02;A61P1/04;A61P1/16;A61P7/02;A61P9/02;A61P9/04;A61P9/10;A61P9/14;A61P11/00;A61P13/12;A61P17/02;A61P19/00;A61P19/02;A61P25/00;A61P25/28;A61P27/02;A61P27/16;A61P29/00;A61P35/00;A61P35/04;A61P41/00;A61P43/00;C07C311/16;C07C311/21;C07C317/22;C07C317/44;C07C323/65;C07D207/14;C07D207/16;C07D207/48;C07D211/16;C07D211/18;C07D211/46;C07D211/54;C07D211/62;C07D211/96;C07D213/30;C07D213/82;C07D295/15;C07D295/26;C07D309/12;C07D401/04;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/12;(IPC1-7):A61K31/445;A61K31/18;C07C317/24;A61K31/40;A61K31/440;A61K31/452;A61K31/496 |
主分类号 |
C07D295/22 |
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