发明名称 |
Orally administrable acid stable antiulcer benzimidazole derivatives |
摘要 |
Orally administrable acid stable anti-ulcer benzimidazole derivatives which are polymer based. The process of preparation comprises condensing a benzimidazole with a biocompatible partially orally biodegradable synthetic cross linked polymer in aqueous medium at 5-80° C. and pH 4-11 under inert atmosphere. The weight percentage of benzimidazole with respect to the polymeric benzimidazole is 1-50. The reaction mixture is cooled and the product is isolated and dried at 25-45° C. There is also provided a formulation of the polymeric benzimidazoles in combination with pharmaceutically acceptable excipients.
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申请公布号 |
US2003023091(A9) |
申请公布日期 |
2003.01.30 |
申请号 |
US20010964442 |
申请日期 |
2001.09.28 |
申请人 |
KOPRAN RESEARCH LABORATORIES LIMITED |
发明人 |
MALI SUBHASH;GUPTE RAJAN;DESHPANDE JAYANT;RANBHAN KAMLESH |
分类号 |
C07D401/12;A61K9/22;A61K31/4184;A61K31/4439;A61K31/787;A61K47/12;A61K47/26;A61K47/32;A61K47/38;A61K47/48;A61P1/04;C08F8/34;C08F20/00;(IPC1-7):C0743/14 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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