摘要 |
<p>The invention relates to synthesised novel hybrid cecropin-melittin peptides having a bactericidal and leishmanicidal activity. Said peptides are derivatives of the lead peptide CA(1-7)M(2-9) and are acylated in one of the amino groups thereof with fatty acids having a variable chain length. In the face of Leishmania, the acylation of the peptides with fatty acids increases the activity of the peptide in relation to both the promastigote and amastigote form thereof. The lethal mechanism is directly related to the permeabilisation of the plasmatic membrane. The inventive peptides provide an extremely useful alternative given the scarcity of novel drugs against Leishmania and the appearance of resistance to antibiotics.</p> |