发明名称 |
USE OF N,N-DIISOPROPYL-4-(7-(4-AMINOPHENOXY)HEPTOXY)-3-METHOXYBENZAMIDE AS PREVENTING AND/OR THERAPEUTIC AGENT FOR OSTEOPOROSIS |
摘要 |
PURPOSE: Provided is N,N-diisopropyl-4-(7-(4-aminophenoxy)heptoxy)-3-methoxybenzamide(DW1259) which has leukotriene-B4 receptor antagonistic action and has excellent effects on inhibition of bone absorption by effectively inhibiting the function of osteoclast cells. CONSTITUTION: The agent for prophylaxis and treatment of osteoporosis contains an effective amount of N,N-diisopropyl-4-(7-(4-aminophenoxy)heptoxy)-3-methoxybenzamide of formula(1). The compound has an excellent inhibition effect on a differentiation, formation, fusion process and bone absorption function of osteoclast cells, is excellent in an inhibition function of osteoclast cells as compared to any compound such as DW1231, DW1234, DW1166, DW1235 having structural similarity as well as HS-1141 and CGS-25019C and has increased efficacy in increasing the activity of osteoblast cells.
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申请公布号 |
KR20030008653(A) |
申请公布日期 |
2003.01.29 |
申请号 |
KR20010043489 |
申请日期 |
2001.07.19 |
申请人 |
DONG WHA PHARM. IND. CO., LTD.;SUH, HONG SUK |
发明人 |
HWANG, YEON HA;JUNG, YONG HO;KIM, DO HUI;KIM, PAN SU;LEE, JIN SU;PARK, YONG YEOP;SUH, HONG SUK;YOO, JE MAN |
分类号 |
A61K31/166;(IPC1-7):A61K31/166 |
主分类号 |
A61K31/166 |
代理机构 |
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