USE OF 4-((4-THIAZOLYL)PHENOXY)ALKOXY-BENZAMIDINE DERIVATIVE AS PREVENTING AND/OR THERAPEUTIC AGENT FOR OSTEOPOROSIS

摘要

PURPOSE: Provided are 4-((4-thiazolyl)phenoxy)alkoxy-benzamidine derivatives(DW1350 and DW1352) acting as leukotriene-B4 receptor antagonistic action. The compounds exhibit an excellent inhibition effect on a differentiation, formation, fusion process and bone absorption function of osteoclast cells, therefore they can be effectively used as an prophylaxis and treatment of osteoporosis. CONSTITUTION: The agent for prophylaxis and treatment of osteoporosis contains an effective amount of 4-((4-thiazolyl)phenoxy)alkoxy-benzamidine derivative of formula(1) or a salt thereof. In formula, R is H or OH. The agent is excellent in an inhibition of osteoclast cells as compared to any compound such as DW1349 and DW1351 having structural similarity as well as HS-1141 and CGS-25019C and has increased efficacy in increasing the activity of osteoblast cells.