发明名称 |
SEPARATING METHOD OF A SINGLE ISOMER FROM THE KETOROLAC OF THE RACEMIC BODY |
摘要 |
PURPOSE: A separating method of a single isomer from the ketorolac of the racemic body is provided, thereby separating the high purity of a single isomer form ketorolac. CONSTITUTION: The separating method of a single isomer from the ketorolac of the racemic body comprises the steps of: reaction of the ketorolac of the racemic body represented by formula(1) with alcohol compounds in the presence of Candida antartica lipase B; and separation of (-)-isomer from the reaction mixture by absorption, wherein the alcohol compounds are C3 to C20 alcohols; the amount of the Candida antartica lipase B is 10 to 150 wt.%; and the reaction temperature is 20 to 70 deg. C.
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申请公布号 |
KR20030008805(A) |
申请公布日期 |
2003.01.29 |
申请号 |
KR20010043741 |
申请日期 |
2001.07.20 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY;KYUNG DONG PHARM. CO., LTD. |
发明人 |
JUNG, CHAN SEONG;KIM, YEONG HUI;LEE, BYEONG SEOK;LEE, SO HA |
分类号 |
C07D487/04;(IPC1-7):C07D487/04 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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