A p387l variant in protein tyrosine phosphatase-1b is associated with type 2 diabetes and impaired serine phosphorylation of ptp-1b in vitro

摘要

The present invention provides an isolated polynucleotide molecule comprising a nucleotide sequence encoding PTP-1B, said nucleotide sequence containing a mutation associated with type 2 diabetes of at least one nucleotide, or comprising a fragment of the nucleotide sequence including said mutation.