发明名称 |
THE ELUCIDATION AND SYNTHESIS OF ANTINEOPLASTIC TETRAPEPTIDEPHENYLAMIDES OF DOLASTATIN 10 |
摘要 |
Dolastatin 10, a linear pentapeptide, has shown potent antineoplastic activity profiles against various experimental cancer systems. The design and synthesis of structural modifications of dolastatin 10 having significant antineoplastic activity against human cancer cell lines has been accomplished. Members of this group have demonstrated significant antineoplastic activity against selected human cancer cell lines. Especially: Ovarian OVCAR-3; Central Nervous System ("CNS") SF295; Renal A498; Lung NCI460; Colon KM20L2 and Melanoma SK-MEL-3.
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申请公布号 |
CA2110556(C) |
申请公布日期 |
2003.01.28 |
申请号 |
CA19932110556 |
申请日期 |
1993.12.02 |
申请人 |
ARIZONA BOARD OF REGENTS |
发明人 |
PETTIT, GEORGE R.;BARKOCZY, JOZSEF |
分类号 |
A61K38/00;A61P35/00;C07K5/02;C07K5/023;(IPC1-7):C07K5/027;A61K38/07 |
主分类号 |
A61K38/00 |
代理机构 |
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