METHOD FOR PRODUCING 2-METHYLSPIRO(1,3-OXATHIOLANE-5,3')QUINUCLIDINE

摘要

PURPOSE: Provided is a method for industrially advantageously producing trans- and cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or a salt thereof useful for the treatment of diseases due to disturbances of central cholinargic function and autoimmune diseases which are so-called Sjogren syndrome, or its intermediate. CONSTITUTION: A method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine comprises condensing 3-hydroxy-3-mercaptomethyl quinuclidine or its salt and a carbonyl compound in the presence of a specific catalyst to manufacture trans- and cis-form 2-methylspiro(1,3-oxathiolane-5,3') quinuclidine or its salt.