发明名称 |
Tri- and tetra-valent monospecific antigen-binding proteins |
摘要 |
The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer.
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申请公布号 |
US6511663(B1) |
申请公布日期 |
2003.01.28 |
申请号 |
US20000664377 |
申请日期 |
2000.09.18 |
申请人 |
CELLTECH R&D LIMITED |
发明人 |
KING DAVID JOHN;TURNER ALISON;BEELEY NIGEL ROBERT ARNOLD;MILLICAN THOMAS ANDREW |
分类号 |
A61K38/00;A61K51/10;C07D207/44;C07D207/452;C07D403/12;C07K5/02;C07K16/00;C07K16/30;(IPC1-7):A61K39/395;A61K39/40;A61K39/42;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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