| 摘要 |
FIELD: organic synthesis. SUBSTANCE: biologically active isoprenoide derivatives of 2,3,5-trimethyl-1,4- benzoquinone are prepared by acid-catalyzed condensation reaction of trimethylhydroquinone with isoprenoide allyl alcohols using as catalyst zeolite-containing aluminosilicate ZSK-5. Reaction is carried out at refluxing for 3-5 h in hydrocarbon solvents at trimethylhydroquinone-to-allyl alcohol molar ratio 1: (1.1-2) and trimethylhydroquinone-to- catalyst weight ratio 1:(1-2), after which catalyst is filtered off, filtrate evaporated, mixed with silica gel, and held in the air at 50-70 C for approximately 0.5 h. Desired product is then isolated with the aid column chromatography on silica gel. EFFECT: extended choice of biologically active compounds. 2 cl, 1 tbl, 3 ex
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