REDUCTION OF ANTIOXIDANT ENZYME LEVELS IN TUMOR CELLS USING ANTISENSE OLIGONUCLEOTIDES

摘要

The present invention provides an antisense oligonucleotide that specifically binds to an antioxidant enzyme start codon so as to inhibit the level of antioxidant enzymes in a cell. The present invention further provides methods of treating an antioxidant enzyme malfunction disorder in a mammal by reducing antioxidant enzyme levels in a cell with the administration of the antisense oligonucleotide.