发明名称 |
PREPARATION OF AMINOPYRIMIDINE COMPOUNDS |
摘要 |
A 2-(N-methyl-N-methanesulfonylamino)pyrimidine compound of the formula (3): [R is a hydrocarbyl group], is prepared by the steps of: (I) reacting an isobutyrylacetate ester with 4-fluorobenzaldehyde and urea in the presence o f a protonic compound and a metal salt; (II) oxidizing the reaction product of the step (I); (III) reacting the oxidation product of the step (II) with an organic sulfonyl halide or an organic sulfonyl anhydride; and (IV) reacting the reaction product of the step (III) with N-methyl-N-methanesulfonamide.</ SDOAB>
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申请公布号 |
CA2453505(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
CA20022453505 |
申请日期 |
2002.07.12 |
申请人 |
ASTRAZENECA LIMITED |
发明人 |
KAWACHI, YASUHIRO;CHIKA, JUN-ICHI;MATSUSHITA, AKIO;ODA, MIZUHO |
分类号 |
C07D;C07D239/22;C07D239/30;C07D239/34;C07D239/36;C07D239/42;C07D239/69;(IPC1-7):C07D239/42 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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