A P387L VARIANT IN PROTEIN TYROSINE PHOSPHATASE-1B IS ASSOCIATED WITH TYPE 2 DIABETES AND IMPAIRED SERINE PHOSPHORYLATION OF PTP-1B IN VITRO

摘要

The present invention provides an isolated polynucleotide molecule comprising a nucleotide sequence encoding PTP-1B, said nucleotide sequence containing a mutation associated with type 2 diabetes of at least one nucleotide, or comprising a fragment of the nucleotide sequence including said mutation.