ANTIOXIDANT AND ANTICANCER PHARMACEUTICAL COMPOSITION CONTAINING MYXOCHELIN-A AS EFFECTIVE INGREDIENT
摘要
PURPOSE: A pharmaceutical composition containing myxochelin-A which exhibits excellent anticancer activity against human cancer cells, together with excellent antioxidant activity as a main component is provided which can be effectively used as an effective antioxidant and anticancer agent. CONSTITUTION: The pharmaceutical composition contains myxochelin-A of formula 1 obtained by being separated from myxobacteria or being chemically synthesized or semisynthesized. The myxochelin-A is purely separated by the steps of: separating a biomass and absorption resin by culturing Angiococcus disciformis strains as myxobacteria in the presence of absorption resin and centrifuging a culture solution; adding an organic solvent, preferably a mixed solvent of acetone and methanol; extracting and filtering to remove the biomass and absorption resin; preparing an active fraction by concentrating the filtrate under reduced pressure and extracting a crude extract in an organic solvent; and successively performing silica gel liquid chromatography and recycling preparative HPLC.
申请公布号
KR20030005787(A)
申请公布日期
2003.01.23
申请号
KR20010041239
申请日期
2001.07.10
申请人
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人
AHN, JONG UNG;CHOI, SANG UN;KWON, JUNG HO;LEE, GYE HYEONG;LEE, HO HYEON;LEE, JEONG OK;NOH, JAE SEONG