发明名称 Molecules that influence pathogen resistance
摘要 The functions of IFNgamma-induced GTPases of the IGTP-family as strong anti-infective agents, and more particularly a strong anti-parasite and/or anti-bacterial agents, are disclosed. These molecules (in both protein and nucleic acid forms) are effective to modify anti-microbial e.g., anti-bacterial and/or anti-parasitic) immune responses in a subject, to prevent or inhibit replication or infectivity of microbe, to treat microbial diseases, and to detect susceptibility of a subject to microbial infection. This invention also provides kits and compounds useful in such methods. Also provided are transgenic non-human animals in which IGTP-family member gene expression has been altered, and the use of such animals to screen for anti-microbial agents.
申请公布号 US2003017985(A1) 申请公布日期 2003.01.23
申请号 US20020169315 申请日期 2002.07.02
申请人 TAYLOR GREGORY ALAN;VANDE WOUDE GEORGE F. 发明人 TAYLOR GREGORY ALAN;VANDE WOUDE GEORGE F.
分类号 A61K38/00;A61K38/46;A61K39/39;C12N9/16;(IPC1-7):A61K38/17 主分类号 A61K38/00
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