ALLELIC VARIANTS OF GPR50

摘要

The present invention provides isolated polynucleotides encoding a receptor gene called GPR50 having at least one polymorphic sites.It furthermore provides a method for analysing polimorphic sites in said receptor gene. Certain of these polynucleotides having a polymorphic site (allelic variants ) are found to be more prevalent in a population of patients with clinical Bipolar Depression compared to a control population. A method for the geneti c testing of Bipolar Depression is a further embodiment of the present invention. Furthermore, polynucleotides encompassing these polymorphic sites , the invariant distal or proximal to the polymorphic site localized polynucleotides as well as the polynucleotides encoding GPR50 are part of th e invention. The present invention also provides a recombinant cell line expressing these novel receptors at appropriate levels such that novel compounds active at these receptors may be identified for therapeutic use.