发明名称 |
CARBOCYCLIC HYDRAZINO INHIBITORS OF COPPER-CONTAINING AMINE OXIDASES |
摘要 |
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO know n as Vascular Adhesion Protein-1 (VAP-1). These SSAO inhibitors have therapeut ic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof, wherein R1 to R11 are as defined herein.
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申请公布号 |
CA2451569(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
CA20022451569 |
申请日期 |
2002.07.11 |
申请人 |
BIOTIE THERAPIES CORPORATION |
发明人 |
VAINIO, PETRI;ALARANTA, SAKARI;SMITH, DAVID JOHN;PIHLAVISTO, MARJO;FUELOEP, FERENC;SZAKONYI, ZSOLT;LAZAR, LASZLO |
分类号 |
C12N9/99;A61K31/15;A61P1/04;A61P3/06;A61P3/08;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/04;A61P25/00;A61P25/02;A61P25/28;A61P29/00;A61P37/00;C07C241/02;C07C243/20;C07D273/00;(IPC1-7):A61K31/15 |
主分类号 |
C12N9/99 |
代理机构 |
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地址 |
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