| 摘要 |
Methods are provided for diagnosing/characterizing chronic immune disease activity in a subject. In the subject methods, the extracellular nuclease activity, measured directly and/or indirectly, of the subject is assayed and the resultant value is employed in the diagnosisis/characterization. More specifically, a sample, e.g., plasma or a fraction thereof, is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for nuclease activity, either directly or indirectly. The assay results are used to diagnose the presence of chronic immune disease and/or characterize chronic immune disease activity in a subject, and/or to determine appropriate treatments protocols. Also provided by the subject invention are methods of treating chronic immune disease conditions by enhancing extracellular nuclease activity. Also provided by the subject invention are kits for practicing the methods.
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