IL−18 TRANSGENIC ANIMAL

摘要

A transgenic non−human mammal having a DNA transferred in such a manner as to express a foreign IL−18 gene specifically in the skin, or its offspring. This transgenic nonhuman mammal spontaneously suffers from atopic dermatitis in the absence of any specific pathogenic microorganism, which makes it useful as a disease model animal. Use of this transgenic animal makes it possible to develop drugs for preventing and treating atopic dermatitis by natural immunity and to clarify the onset mechanism of atopic dermatitis.