BIODEGRADABLE PHARMACEUTICAL COMPOSITION ENABLING SUSTAINED RELEASE OF HUMAN GROWTH HORMONE AND MICROSPHERE THEREOF

摘要

PURPOSE: A microsphere containing a drug obtained by adding polyethylene glycol as a protein stabilizer in an appropriate ratio and then including human growth hormone into the microsphere is provided which enables the human growth hormone to continuously release from the microsphere for two weeks even in vivo as well as in vitro. CONSTITUTION: The microspherical composition contains human growth hormone, polyethylene glycol or a derivative thereof as a protein stabilizer, a biodegradable polyester polymer as a polymer carrier, a surfactant and an emulsifier, wherein the human growth hormone and polyethylene glycol or a mixture thereof are dispersed in a droplet of the surfactant to form a first emulsion. The first emulsion is dispersed in the droplet of the emulsion.