USE OF ELECTROLYTES (IONS IN SOLUTION) TO SUPPRESS CHARGING OF INHALATION AEROSOLS

摘要

Formulations are disclosed as are aerosols created therefrom. The formulations are comprised of (a) a pharmaceutically active drug which does not ionize in solution; (b) an electrolyte; and (c) a solvent which is preferably water and/or ethanol. The electrolyte reduces electrostatic charging on particles of aerosol formed thereby enhancing characteristics of the aerosol particles which are important for efficient, repeatable intrapulmonary drug delivery. A method is disclosed whereby molar amounts of charged molecules are adjusted so as to reduce electrostatic charge on aerosolized particles created from the formulation whereby the particles are less inclined to be drawn against surfaces of a patient's upper respiratory tract.