| 摘要 |
The present disclosure provides new highly sensitive probes for the detection of neoplasms, including breast and other cancers. The probes bind selectively with target polynucleotide sequences found on the long arm of Chromosome 17, more particularly the region 17q23. In particular, such probes are to RAD51C, S6K, PAT1/APPBP2, TBX2, MUL, TRAP240, AA806470, AA635172, stSG39547, or G29449. Amplification or other mutation of any of RAD51C, S6K, PAT1/APPBP2, TBX2, MUL, TRAP240, AA806470, AA635172, stSG39547, or G29449 is frequently linked to cancer. Methods of using RAD51C, S6K, PAT1/APPBP2, TBX2, MUL, TRAP240, AA806470, AA635172, stSG39547, or G29449 biological materials in the diagnosis and treatment of neoplasia, and particularly breast cancer, are presented.
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| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, ASREPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE NATIONAL INSTITUTES OF HEALTH;KALLIONIEMI, ANNE, H.;MONNI, OUTI, M.;BAERLUND, MAARIT, T.;KONONEN, JUHA, T.;KALLIONIEMI, OLLI, P. |
发明人 |
KALLIONIEMI, ANNE, H.;MONNI, OUTI, M.;BAERLUND, MAARIT, T.;KONONEN, JUHA, T.;KALLIONIEMI, OLLI, P. |
