COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING CONDITIONS, DISORDERS, OR DISEASES INVOLVING CELL DEATH

摘要

The present invention relates to compositions and methods for the treatment and diagnosis of conditions, disorders, or diseases involving cell death, including protective nucleic acids which, when introduced into a cell predisposed to undergo cell death or in the process f undergoing cell death, prevent, delay, or rescue the cell from death. The invention encompasses nucleic acids of the protective sequence, host cell expression, and transgenic animals, as well as protective sequence products, antibodies directed against such products, and target sequences involved in cell death. The present invention also relates to methods and compositions for the diagnosis and treatment of conditions, disorders, or diseases involving cell death, including those involving the central or peripheral nervous system. The invention relates to methods of using the protective sequence, products, and/or regulatory elements to identify compounds that modulate the expression of the protective sequence and/or the activity of the protective sequence product.