| 摘要 |
The present invention provides methods for inhibiting the proliferation of disease-causing pathogens. More particularly, the present invention provides methods for the localization and recovery of surface exposed immunogenic polypeptides (SEIP) of microbes, such as bacteria, fungi, and protozoa, which are involved in the adhesion of such pathogens to host cell surfaces, and the adhesion of iron-binding molecules to pathogen cell surfaces. Further, the SEIPs of the present invention are used as substrates to recover high affinity nucleic acid antibodies. Such isolated high-affinity nucleic acid antibodies are then used to bind pathogenic SEIPs so as to inhibit proliferation of the pathogen. The nucleic acid antibodies of the present invention are hence useful for the prevention, diagnosis, and treatment of pathogenic diseases and infections. |
