发明名称 |
SUSTAINED-RELEASE LOCALLY ADMINISTRABLE ANTICANCER PREPARATION FOR TREATMENT OF BRAIN TUMOR |
摘要 |
PURPOSE: A sustained release anticancer agent containing a biodegradable polymer and water-soluble synthetic polymer including an nitrosourea-based anticancer agent is provided which can be locally administrated into the tumor or a tumor-removed portion in the shape of a disk, film or rod. CONSTITUTION: The anticancer preparation contains a nitrosourea-based anticancer agent and a biodegradable polymer, wherein 0.01 to 40% by weight of the nitrosourea-based anticancer agent is included by 60 to 99.99% by weight of the biodegradable and water-soluble synthetic polymer and the water-soluble polymer is contained in the range of 1 to 50% by weight, based on the biodegradable polymer. The biodegradable polymer has an average molecular weight of 5,000 to 1,000,000 and is selected from polylactide, polyglycolide, a lactide-glycolide polymer, polyhydroxy butyric acid, polycaprolactone and polyalkylcyanoacrylate.
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申请公布号 |
KR20030005997(A) |
申请公布日期 |
2003.01.23 |
申请号 |
KR20010041533 |
申请日期 |
2001.07.11 |
申请人 |
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY |
发明人 |
KANG, GIL SEON;KANG, HUI JEONG;LEE, HAE BANG;LEE, JEONG SIK;MUN, DAE SIK;SUNG, HA SU |
分类号 |
A61K47/30;(IPC1-7):A61K47/30 |
主分类号 |
A61K47/30 |
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