发明名称 |
IMIDAZOLE DERIVATIVES AS ADENOSINE DEAMINASE INHIBITORS |
摘要 |
Imidazole compounds having adenosine deaminase inhibitory activity represented by the formula (I)wherein R1 is aryl or heterocyclic group which is optionally substituted with substituent(s);R2 is lower alkyl;R3 is hydroxy or protected hydroxy;- A - is lower alkylene; and- X - is - O - or - S -;provided that when - X - is - O -, then R1 is aryl which is substituted with substituent(s), or heterocyclic group which is optionally substituted with substituent(s),its prodrug, or their salt. The compounds are useful for treating and/or preventing diseases for which adenosine is effective.
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申请公布号 |
WO03006437(A1) |
申请公布日期 |
2003.01.23 |
申请号 |
WO2002JP06983 |
申请日期 |
2002.07.10 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD.;TERASAKA, TADASHI;KATO, TAKESHI;TSUJI, KIYOSHI;NAKAMURA, KATSUYA |
发明人 |
TERASAKA, TADASHI;KATO, TAKESHI;TSUJI, KIYOSHI;NAKAMURA, KATSUYA |
分类号 |
A61P29/00;C07D233/54;C07D233/90;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/12;(IPC1-7):C07D233/90;A61K31/417 |
主分类号 |
A61P29/00 |
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