SYSTEM AND METHOD FOR DIFFERENTIAL PROTEIN EXPRESSION AND A DIAGNOSTIC BIOMARKER DISCOVERY SYSTEM AND METHOD USING SAME

摘要

A cell protein profiling and diagnostic system is provided that fractionates (110) a protein content of a tissue sample into prot ein subgroups, independently performs mass spectroscopy (120) on each protein subgroup, creates a cell expression protein profile from the mass spectra, and identifies protein patterns associated with subject characteristics, such as biological conditions and diseases, based on the cell expression protein profile. In one embodiment, the protein patterns are identified with an artificial neural network, or other data mining or pattern recognition techniques.