| 摘要 |
PURPOSE: Provided are a pharmaceutical composition and a package containing carprofen and derivatives for treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals. CONSTITUTION: A pharmaceutical composition and package for treating or preventing the early stages of degeneration of articular cartilage or subchondral bone in mammals is characterized by containing carprofen and derivative represented by the formula(1), wherein where A is hydroxy, (C1-C4)alkoxy, amino, hydroxy-amino, mono-(C1-C2)alkylamino, di-(C1-C2)alkylamino; X and Y are independently H or (C1-C2)alkyl; and n is 1 or 2; R6 is halogen, (C1-C3)alkyl, trifluoromethyl, or nitro; R9 is H; (C1-C2)alkyl; phenyl or phenyl-(C1-C2)alkyl, where phenyl is optionally mono-substituted by fluoro or chloro; -C(=O)-R, where R is (C1-C2)alkyl or phenyl, optionally mono-substituted by fluoro or chloro; or -C(=O)-O-R', where R1 is (C1-C2)alkyl.
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