DIPHENYLALKYLAMINE DERIVATIVES USEFUL AS OPIOID DELTA RECEPTOR AGONISTS

摘要

A substance having affinity for an opioid delta receptor, which is represented by the following general formula (I): <CHEM> wherein, X represents a group of the general formula: -CO-N(R<5>)(R<6>) (II) and the like, n represents 1 to 3, R<1> and R<2> represent a hydrogen atom, a halogen atom, a lower alkyl group and the like, R<3> represents a hydrogen atom, a halogen atom, a lower alkyl group and the like, R<4> represents a saturated or unsaturated monocyclic or bicyclic carbocyclic group and the like, R<5> to R<12> represent a hydrogen atom, a lower alkyl group and the like, and R<3> and R<4>, R<5> and R<6>, R<7> or R<8> and R<9> and R<10> may bind to each other to form a cyclic structure, and a medicament useful for preventive and/or therapeutic treatment of central nervous system diseases and peripheral nervous system diseases comprising the substance as an active ingredient.