Lactams substituted by cyclic succinates as inhibitors of Abeta protein production

摘要

This invention relates to novel lactams having the Formula (I):to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Abeta-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta-amyloid production such as Alzheimer's disease and Down's Syndrome.