ISOXAZOLYL-PYRIMIDINES AS INHIBITORS OF SRC AND LCK PROTEIN KINASES

摘要

The present invention provides compounds of formula I or a pharmaceutically acceptable derivative thereof, wherein A-B is N-O or O-N and G, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of Src and Lck kinase. The invention also provides pharmaceutical compositions comprising the inhibitor s of the invention and methods of utilizing those compositions in the treatmen t and prevention of various disorders.