发明名称 |
INTERACTION OF TBX2 AND THE ARF PROMOTER IN CELL CYCLE REGULATOR ASSAYS |
摘要 |
The present invention provides an assay for a modulator of cell cycle progression, which comprises: a) bringing into contact a TBX2 protein, an ARF promoter TBX-2 binding region and a putative inhibitor compound under conditions where the TBX2 protein and the binding region, in the absence of inhibitor, are capable of forming a complex; and b) measuring the degree of inhibition of binding or transcriptional activation caused by said inhibitor compound.The invention further provides a method for the diagnosis or prognosis of breast cancer which method comprises determining the amount of TBX2 nucleic acid or protein in a cell which cell is, or is suspected to be, a breast tumour cell or metastatic cell from a breast tumour. |
申请公布号 |
WO0198530(A3) |
申请公布日期 |
2003.01.16 |
申请号 |
WO2001GB02706 |
申请日期 |
2001.06.19 |
申请人 |
VERENIGING HET NEDERLANDS KANKER INSTITUUT;PROLIFIX LIMITED;VAN LOHUIZEN, MAARTEN;JACOBS, JACQUELINE;VAN DE VIJVER, MARC |
发明人 |
VAN LOHUIZEN, MAARTEN;JACOBS, JACQUELINE;VAN DE VIJVER, MARC |
分类号 |
G01N33/574;G01N33/68 |
主分类号 |
G01N33/574 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|