GENETICALLY ENGINEERED THERAPY METHOD FOR TREATING GNRH RECEPTOR-POSITIVE CARCINOMA BY GNRH-INDUCED TUMOR CELL-SPECIFIC ACTIVATION OF A THERAPEUTIC GENE, CORRESPONDING NUCLEIC ACID CONSTRUCTS AND VECTORS

摘要

GnRH-induced NFKB activation can be used for the tumor cell-specific of an introduced effector gene under the control of an NFKB-dependent promoter. To achieve this, the tumor cells are transfected with a vector that contains the effector gene under the control of the NFKB promoter. Said gene is then activated in a target cell-specific way by the activation of NFKB through GnRH agonists so that an inactive pro-substance (prodrug) is reacted to a cytotoxic substance only in GnRH receptor-carrying tumor cells, thereby allowing for a target cell-specific cytotoxic therapy.