摘要 |
<p>The invention relates to a method for screening molecules which can bind to the gp 120 protein of the immunodeficiency virus. The inventive method uses the fluorescene anisotropy technique and the peptide of the following formula (I): TPA- Xaaa- Xaab- Ala or Gln or His - Arg ou Phe - Cys - Xaac- Xaad- Arg - Cys - Lys - Xaae- Xaaf- Xaag- Xaah- Leu ou Lys - Xaai - Lys - Cys - Ala or Gln - Gly or (D)Asp or Ser - Ser or His or Asn - Xaaj- Cys - Thr or Ala - Cys - Xaak-NH2, (I) wherein TPA represents thiopropionic acid, Xaaa, Xaab, Xaac, Xaad, Xaae, Xaaf, Xaag, Xaah, and Xaai are naturals or non natural amino acids which are identical or different, Xaaj represents b-naphtylalanine or phenylalanine or bi-phenylalanine, and Xaak represents Gly or Val or Ile.</p> |